Resveratrol effects on Ataxia Telangiectasia Mutated in vitro
This is simply my notes and reading list entries of today.
I am investigating several neurodegenerative diseases pathologic mechanisms.
This involves pathways involved in autophagy but with very detailed nuances.
So ATM (Ataxia Telangiectasia Mutated) Activation.
A process that mitigates DNA damage recognition, signaling, and repair.
https://www.ncbi.nlm.nih.gov/pubmed/24933654
It is on human derived cell lines.
Resveratrol effects on ATM activation for cancer proliferation mitigation.
So essentially via ROS (reactive oxygen species) promoted activation, resveratrol, is an ATM activation agonist.
So as a thought experiment I play with this idea to see how it might fit in to a "program" to preserve neurological homeostasis in a genetically compromised individual with a mutation that affects this pathway.
At first sight it looks like resveratrol qualifies as an intervention.
I am investigating several neurodegenerative diseases pathologic mechanisms.
This involves pathways involved in autophagy but with very detailed nuances.
So ATM (Ataxia Telangiectasia Mutated) Activation.
A process that mitigates DNA damage recognition, signaling, and repair.
https://www.ncbi.nlm.nih.gov/pubmed/24933654
It is on human derived cell lines.
Resveratrol effects on ATM activation for cancer proliferation mitigation.
So essentially via ROS (reactive oxygen species) promoted activation, resveratrol, is an ATM activation agonist.
So as a thought experiment I play with this idea to see how it might fit in to a "program" to preserve neurological homeostasis in a genetically compromised individual with a mutation that affects this pathway.
At first sight it looks like resveratrol qualifies as an intervention.
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